Regional Innovation Cluster Program (City Area Type) Takamatsu Creation of a health-related bioindustry based on the functionality of characteristic sugars



Aims of Project

In the Takamatsu area, technological systems have been established for the production of rare sugars (monosaccharides that exist only in small amounts in nature) ,and research has been undertaken into the biological activities of these sugars. The structures and functions of these rare sugars have been claritied using funds provided by national and local governments.

This Regional Innovation Cluster Program aims to promote the commercial production of rare sugars by utilizing research results. By carrying out intensive R&D and by commercializing functional foods, skin-care products, diagnostic products, intermediates for the synthesis of medicals,and other ptoducts, this project is expected to promote the development of the food industry and related industries in this area, leading to innovation in the health-related bioindustry in readiness for the aging of society.

Contents of Project

Theme 1: Development of Food for Specified Health Uses having biological functions of the rare sugar, D-psicose.

Improved coloring and antioxidant properties of spong cake baked in the presence of added D-psicose

Inhibitory effect of D-psicose on the elevation of blood glucose levels following meals

(A) Development of psicose-added foods which have enhanced health beneficial effects.

Various food products added with D-psicose including confectionaries, bakery, processed marine products will be prepared and the chemical changes of D-psicose and other characteristics of the foods will be clarified. Finally, by sensory evaluation of the products, foods having outstanding functions will be developed.

(B) Elucidation of physiological functions of rare hexoses including D-psicose for anti-diabetic, anti-atherosclerotic and anti-obesity purposes.

Kinetics in the body, organ distribution, metabolism and excretion of D-psicose are studied using normal healthy rats. Anti-diabetic and anti-obesity effects of D-psicose are studied using diabetic model animals, and results will be used for the development of healthy foods.

Theme 2:Development of foods and other products utilizing the immuno-regulatory functions of glyco-related materials obtained from regional agricul-tural and marine resources.

Macrophage with an immunity-adjustment action(fluorescent photomicrograph)

(A) Development of health care products utilizing a biomaterial(fermented-flour extract).

We will develop foodstuffs and skin-care products that containglycolipids as active substances from Pantoea agglomerans-fermented flour, to combat lifestyle-related diseasea and allergies.

(B) Whitening and immunopotentiating mechanisms, and the use in cosmetics of polysaccharides from marine bacteria.

Beauty lotion having excellent antiaging effect will be developed by utilizing glycosaminoglycan produced by marine bacteria.

(C) Development of functional foods using physiologically active glycolipids isolated from olives.

We will establish a method of preparing an immunity-regulating glycolipid from olives, and then develop functional foods using this glycolipid.

(D) Biological functions of oligosaccharides from brown algae.

We will establish a mass-production system for β-1,3(6)-glucan and its partial depolymerization products(oligosaccharides) obtained from brown algae. These products will be applied to aquatic food and animal feed.

Theme 3:Chemoenzymatic synthesis of rare-sugar-based intermediate materials for pharmaceutical drugs and chemical products.

Non-naturally occurring sugars have attracted attention as intermediate materials for pharmaceutical drugs and agricultural chemicals. The objective of this research is to chemoenzymatically synthesize and characterize rare-sugar-based intermediate materials such as oligo- and polysaccharides, glycosides, and glycopolymers.

Theme 4:Development of novel cancer markers by Glycan Analysis.

This project is intended to investigate oligosaccharide markers in serum originally expressed in breast cancer, and hence, develop useful detection probes (antibodies) for cancer diagnosis.

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Collection of Technological Achievements Related to Rare Sugars

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Cultural assets

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